Sentences with phrase «bone metastases»
"Bone metastases" refers to cancer cells that have spread from their original location to the bones. Full definition
(L) Bioluminescent images of bone metastases from representative mice at day 18 after inoculation.
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The indication now covers patients with bone metastases from solid tumors and those with multiple myeloma.
After a recent announcement of the results of a Phase 3 trial of Amgen's drug denosumab in the treatment of bone metastases in over 2,000 patients with advanced breast cancer, Perlmutter says he received many messages from employees who were supportive of the research.
We found that ABL kinase knockdown increased the survival of tumor - bearing mice (Fig. 2B) and markedly inhibited bone metastases by 1833 and SCP28 breast cancer cells as measured by bioluminescence imaging (Fig. 2, C to F) and hematoxylin and eosin (H&E) staining (Fig. 2, G and H).
Recalcification of bone metastases by calcium diorotate.
Treatment in a mouse model of metastatic breast cancer with two of the down - regulated miRNAs (miR - 141 and miR - 219) suppressed bone metastases, suggesting that these miRNAs may have therapeutic utility.
Bone metastases happen when cancer cells travel from the primary tumor site to the bone, establishing a new cancer location.
Radium - 223 dichloride (radium - 223 for short, trade name: Xofigo) has been approved since November 2013 for men with advanced prostate cancer, in whom hormone blockade is no longer effective, and symptomatic bone metastases, but without visceral metastases.
The patients with bone metastases did not necessarily have an elevated prostate specific antigen level.
Engineering a humanized bone organ model in mice to study bone metastases.
(D) Quantification of bone metastases.
By emitting radiation from nearby areas, the drug aims to inhibit bone metastases.
Bone metastases occur in up to 70 % of advanced breast cancer.
miR - 34a could have an additional therapeutic application, offering protection from bone metastases in a variety of cancers, Dr. Wan noted.
Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.
It is the failure of organ systems and bone metastases.
The up - regulated miRNAs proved interesting for a different reason: Two of them (miR - 16 and miR - 378) were detected in the blood of tumor - bearing mice and correlated with metastatic burden, suggesting that they may be useful biomarkers of bone metastases.
UT Southwestern cancer researchers have identified a promising molecule that blocks bone destruction and, therefore, could provide a potential therapeutic target for osteoporosis and bone metastases of cancer.
The majority of metastatic specimens were lung metastases but also included several other visceral sites, skin, soft tissue and soft tissue components of bone metastases.
For most patients with breast cancer, bone metastases are predominantly osteolytic.
«We found not only an effect on bone metastases, which one might have anticipated, but also on local regional recurrence, distant bone metastases and contralateral breast cancer,» said study author Dr. Michael Gnant, a professor of surgery at the Medical University of Vienna.
A recent study published also shows acupuncture can reduce pain from bone metastases.
Cats may be lame due to bone metastases and most cats are anemic.
Fosamax Injury Cases Unfortunately, Fosamax, which is a bisphosphonate that is prescribed to women suffering from osteoporosis (as well as Paget's disease, bone metastases, and other bone diseases) has been linked to some serious side effects that are calling into question whether the drug's supposed benefits - decelerating bone loss while increasing bone density - are worth it.