Electrophysiological refers to the branch of science that studies the electrical activity in living organisms, such as the brain or muscles. It involves measuring and analyzing the electrical signals generated by these organisms to understand how they function and communicate.
Full definition
The pair also developed a novel approach of
electrophysiological recordings and optogenetics to examine how exactly the double - projecting neurons connected to the mPFC and amygdala.
Based on evidence from
electrophysiological studies showing that both synaptic plasticity and strength of inputs to hippocampal region CA1 vary systematically with ongoing theta oscillations (Hyman et al., 2003; Brankack et al., 1993), it has been suggested that the theta rhythm functions to separate periods of encoding of current sensory stimuli and retrieval of episodic memory cued by current stimuli so as to avoid interference that would occur if encoding and retrieval were simultaneous.
And although the study was on the small side — just 12 participants — the research was unique in that it
used electrophysiological measurements for an objective evaluation.
By performing
electrophysiological measurements, the scientists were able to quantify the flies» responses to limonene and to localize and identify the olfactory sensory neurons responsible for detecting citrus.
Whereas geneticists know when they've finished decoding a stretch of DNA, brain mappers lack clear stopping points and wrestle with much richer sets of imaging and
electrophysiological data — all the while wrangling over the best ways to collect, share and interpret them.
The Gottfried Laboratory in the Departments of Neurology and Psychology at the University of Pennsylvania is looking to hire a post-doctoral researcher to study the olfactory system using intracranial
electrophysiological methods in patients with medically resistant epilepsy.
So far, these arrays have been used to record
electrophysiological responses of individual neurons within the hippocampus, a subregion of the brain responsible for memory formation.
Furthermore, the researchers employed
electrophysiological measuring methods and observed that neuronal activity in the PL significantly decreased prior to the premature reactions when all regions were intact.
His lab also
performed electrophysiological tests, which demonstrated that the new neurons converted by the NeuroD1 retrovirus could receive neurotransmitter signals from other nerve cells, suggesting that the newly converted neurons had successfully integrated into local neural circuits.
This, explains Greco, facilitates the measurement of
electrophysiological signals of patients and athletes over a longer period without restricting or influencing their normal activities.
«We were able to detect periods of mind wandering through distinctive
electrophysiological brain patterns, some of which indicated that the drivers were likely less receptive to external stimuli,» says Baldwin.
A 50 % reduction in HDAC4 restored these and other
electrophysiological changes in both the R6 / 2 model, a transgenic over-expresser of Exon 1 HTT with an expanded polyglutamine repeat, and heterozygous Q175 knock - in mice (Q175 + / --RRB-, which carry one normal and one mutant HTT allele with an expanded repeat of ~ 190 polyglutamines, in addition to reversing behavioral alterations in R6 / 2 mice (Mielcarek et al, 2013; PLOS Biology, in press).
Her research has focused on refining noninvasive
electrophysiological approaches for evaluating retinal and anterior visual pathway function in normal subjects and subjects with inherited or acquired diseases that affect visual function.
Cloning in RNA expression vectors was combined with a sensitive
electrophysiological assay in Xenopus oocytes in order to isolate a functional cDNA clone encoding the 5HTlc serotonin receptor.
Electrostatic properties of the side portals and positions of the T1 domain and β subunit are consistent
with electrophysiological studies of inactivation gating and with the possibility of K + channel regulation by the β subunit.
Functional assessment of Brn3b / Thy1 cells using whole cell patch recordings found similar
electrophysiological characteristics between iPSC - derived RGCs and those isolated from rat and primate retina.
In Dr. Scott's lab Paul worked
on electrophysiological studies of neural representations of motor skills in non-human primates.
«Moreover, we confirmed optical modulation of
specific electrophysiological responses from different neuronal units in the thalamus part of the brain, in response to particular types of pain - stimuli.»
Differential Sarcomere and
Electrophysiological Maturation of Human iPSC - Derived Cardiac Myocytes in Monolayer vs. Aggregation - Based Differentiation Protocols.
High throughput
electrophysiological screening of Xenopus oocytes expressing exogenous genes in the frame of pharmacological or agricultural projects.
Working with motor neurons derived from ALS patients and healthy controls, Dr. Wainger performed fundamental
electrophysiological characterization and identified motor neuron hyperexcitability in ALS patient - derived motor neurons (Wainger et al., 2014).
But, rather than studying the entire nervous system of a single model organism, Professor Graybiel has studied one brain region — a portion of the basal ganglia known as the striatum — in mice, rats, cats, monkeys, and humans using a whole range of technologies from microscopy
through electrophysiological recordings to genetics.
Her laboratory has successfully
combined electrophysiological expertise with molecular and cell biology approaches to better understand complex mechanisms underlying the memory process in mouse models of AD.
«We observed no serious side effects in patients treated with dTMS, and it is therefore worth stressing the tolerability of this
noninvasive electrophysiological technique,» says Prof. Paul, the study's principal investigator.
Nerve conduction studies in motor and sensory nerves of the macaques showed that the Bb infection resulted in specific
electrophysiological abnormalities (increased F wave latencies and chronodispersion) that could be prevented with dexamethasone.
They showed significantly higher measurements of specific
electrophysiological parameters, known as beta and theta oscillations, in brain regions called the right temporal lobe and bilateral occipital cortex.
These findings were confirmed by two - photon imaging of neurons in the brains of living mice by the lab of collaborator Yi Zuo, PhD, a neuroscientist at UC Santa Cruz, as well
as electrophysiological recordings from neurons in brain slices by the lab of collaborator Vikaas Sohal, MD, PhD, an associate professor of psychiatry at UCSF.
Using a multi-disciplinary approach
involving electrophysiological, cellular and biophysical techniques, the researchers found that parts of the prion protein lacking the «brake» region produced abnormal electrical currents in cells.
The few cells that did differentiate into motor neurons showed functional defects in their dendrites and
altered electrophysiological properties.
Such studies integrate several research tools including classic animal dissections, histocytochemistry, immunohistochemistry, electron microscopy, kinematics & motion analysis, electromyography, and
other electrophysiological techniques.
A highly
specialized electrophysiological technique, microneurography, has been shown to be valid for measurements in animals and in human volunteers and patients.
Two structurally distinct lead series compounds have been evaluated in a battery of HD model interrogations, including R6 / 2 in vivo behavioral and survival endpoints and HD model ex
vivo electrophysiological and molecular readouts following chronic dosing.
And, perhaps most strikingly, a team at a gaggle of New York research institutions published a paper showing how they'd used hPSCs to cook up — in just days, rather than several months — cortical neurons (critical central nervous system cells) that had
normal electrophysiological signaling properties.
Within a few
years electrophysiological and functional imaging experiments will inform us whether the animals show increased processing in the regions of visual cortex dedicated to color perception.
A 2004 paper in the Journal of Clinical Neurophysiology that reviews the «
electrophysiological undercurrents for Dr. Frankenstein» notes that Shelley could not have missed the widely discussed work of Giovanni Aldini, Galvani's nephew, who in 1803 zapped the heads of decapitated criminals in an attempt to reanimate them; he imagined this could be used to resuscitate people who had drowned or suffocated and possibly to help the insane.
According to Bolshakov, Carlezon, and fellow study researcher Yan Li, PhD, this ability to definitively detect and
distinguish electrophysiological changes suggests that this study's methodology provides a stronger link between immune activation and brain disorders versus studying behavioral effects alone.
Now that the location of the voice area in the macaque brain has been established, researchers will obtain critical additional information in the near future by exploring the monkey's voice area using more
conventional electrophysiological techniques, such as recording directly from neurons.
«This new chip enables us to perform
live electrophysiological measurements to assess the integrity of the endothelial barrier in the heart using TEER measurements, while simultaneously quantifying the beating frequency of the heart cells using MEA.
Phrases with «electrophysiological»