The variant has been found in two men with prostate cancer, and in vitro analysis suggests it causes a partial loss
of function of the gene.
But such similarities are inherently intellectually sterile, unless the
biological functions of the genes have been established for one or more of the species being compared.
We study learning and memory at the genetic level to understand the structure, regulation, evolution and
biological function of genes that are required for normal learning and memory.
Genetics (GEN): The study of molecular genetics focusing on the structure and
function of genes at a molecular level.genes, genetic variation, and heredity in living cells.
Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the
specific function of those genes and gene networks.
Furthermore, despite the claim that evolution has no application, phylogenetic comparisons of humans and other organisms allows us to identify the precise location and
putative function of genes responsible for developmental disorders.
Published in GigaScience, the open source Galaxy workflow allows researchers to make easier work of finding gene families; an important tool when it comes to analysing the evolution, structure and
function of genes across species.
Researchers at VCU Massey Cancer Center have uncovered a
novel function of the gene PLK1 (polo - like kinase 1) that helps prostate cancer cells metastasize (spread) to other parts of the body.
The
precise function of these genes is unknown, but previous research suggests they may be involved in removing a protein fragment called beta - amyloid from the brain.
«Solving a genetic mystery in type 1 diabetes: Research
unveils function of gene associated with higher risk of autoimmune attack.»
Also relevant are studies of the upstream mechanisms that regulate levels and
function of those gene products, for example: how a transcription factor regulates multiple targets or how factors can regulate translation or post-translational modification of multiple proteins.
In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss
of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).
Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the
specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.
Essentially the model reproduces the inner workings of all of the proteins within the organism and allows scientists to see everything from how cells interact with each other to
the functions of genes in a larger context that had not been previously understood.
Genetic modification is a useful tool to help understand
the function of genes.
Genetic modification is a useful tool to help us understand
the function of genes.
The answers could help open many doors in medicine and greatly expand our understanding of
the functions of genes.
Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and
the function of those genes, in a way similar to analyses of human social networks.
The function of the EST — or at least
the function of the genes from which they are derived — is therefore known.
Although
the function of the gene isn't fully established, it is thought to add sugars to proteins, which could alter the speed or specificity of their usual function.
With rapid advances over the past 10 years in technologies for discovering and analyzing
the functions of genes, researchers are now increasingly able to get at the biological roots of complex disorders such as substance abuse and addiction.
... What we learn improves our knowledge about
the function of these genes in other animals, including humans.»
While earning a master's degree in biology at the University of Vienna in his native Austria, he spent more than a year researching
the function of genes in bone development and cancer in Erwin Wagner's lab, which was located at the Research Institute of Molecular Pathology (IMP) in Vienna.
Understanding
the function of this gene — described this month in journal Molecular Psychiatry — could lead to more effective treatments for schizophrenia.
All this enabled them to systematically whittle away genes that either had nonessential functions or duplicated
the function of another gene.
However, resistance to therapy might go beyond cancer mutations that usually alter
the function of genes.
Discovering
the function of a gene requires cloning a DNA sequence and expressing it.
These adducts may also change
the functions of genes that promote or suppress disease, although exactly how they might lead to developmental decrements in fetuses exposed to them is unclear.
Researchers at the ARC Centre of Excellence in Plant Energy Biology at the University of Adelaide's Waite campus then investigated
the function of this gene.
Dr Yalda Jamshidi, Senior Lecturer in Human Genetics, St George's University Hospital Foundation Trust, said: «Inherited genetic conditions often result because
the function of a gene is disrupted.
In the next phase of the study, we will examine and categorize
the functions of the genes that we identified — not only in model organisms, but also in agriculturally and economically important crops such as corn.»
IMPC builds on the groundwork and achievements of EUMODIC in establishing the procedures and processes to identify and catalogue
the function of genes.
«Certainly, a lot of details are still unclear especially with regard to
the function of genes.
Although
the functions of these genes match well with the environment in which woolly mammoths were known to live, Lynch warns that it is not direct proof of their effects in live mammoths.
«To have an idea of what these genes might do, I searched a database that describes
the functions of genes in the mouse and found that mice that have a deletion of the Maged1 gene have neurocognitive behavioral abnormalities.
The difficulties are well illustrated by last month's rejection of a patent application in the US, by the Institutes of Health, for DNA sequences without knowledge of
the function of the gene.