These molecules reduce leptin's ability to communicate with the brain and are the primary cause
of leptin resistance.
One of the most common reasons my patients have a difficult time losing weight is because of something
called leptin resistance.
Just like insulin resistance, you will
develop leptin resistance where in you need more leptin to be released to get the message across.
However, as more leptin is produced by increasing numbers of fat cells, those same fat cells become less sensitive to the leptin they are working hard to produce,
creating leptin resistance.
You could reverse
leptin resistance by eliminating simple sugars and processed foods from your diet, replace them with natural whole foods and adjusting your calorie intake to your physical activity.
High thyroid antibodies alone, inflammation and active autoimmune process are all factors that affect leptin pathways and
increase leptin resistance even if your thyroid lab results are normal.
It's this impaired signaling by inflammation, like a couple with bad communication skills, that
drives leptin resistance.
Levels above 10 may
suggest leptin resistance, which means the body believes it is starving, and works to increase fat stores and fails to burn stored fat.
Insulin and
leptin resistance not only drive you to store fat; they increase inflammation and affect your levels of estrogen and testosterone.
Note that normal laboratory ranges can not be used for
determining leptin resistance, because these ranges include both overweight and insulin resistant individuals.
Treatment: There are currently two medications are shown to be able to
treat leptin resistance and can result in significant weight loss.
Start working out regularly, as workout has a huge positive influence on your hormones, including reversing the effects
of leptin resistance.
When leptin is unable to produce its normal effects, which naturally stimulate weight loss, this is known
as leptin resistance.
However, over time chronic excessive release of leptin will
create leptin resistance, which is what we find in common obesity.
Differential Mechanisms and development of
leptin resistance in A / J versus C57BL / 6J mice during diet - induced obesity.
Researches from St. Louis and Japan (Banks A, Coon AB, Robinson SM, Moinuddin A, Shultz JM, Nakaoke R, Morley JE, et all, Triglycerides induce
leptin resistance at the blood - brain barrier) figured out that triglycerides, which are fats found in the blood stream interrupt the passage of leptin across the blood brain barrier.
Leptin resistance occurs when your body stops recognizing this hormone and tricks your metabolism into thinking it's starving — causing it to continually store fat instead of burning it off.
The participants changed their body composition and also decreased leptin levels, which should help them
improve leptin resistance — keeping hunger and satiety better managed for weight loss.
Research also suggests
leptin resistance plays a key role in the obesity epidemic, however, researchers are still not clear on the exact mechanisms which trigger this condition.
As mentioned in this post
on leptin resistance and how to reverse it, our fat cells do more than just store energy and keep us warm — they secrete a hormone called leptin.
The conventional frequency of feeding advice is well - intended but has unintended consequences which can tend toward the development of
Leptin Resistance because of the constant leptin signalling the hypothalamus receives.
Because if you can't make the extra fat around your belly, hips, and thighs budge despite healthy eating and exercising, then you are already
experiencing leptin resistance.