"muscle regeneration" refers to the process of repairing and rebuilding muscles in the body. When our muscles get injured or damaged, this natural ability allows them to recover and become strong again. It involves the growth of new muscle cells and the repair of existing ones, helping us regain strength and function in our muscles after injury or intense exercise.
Full definition
The authors were led into the realm of muscle and sex when they realized that they were relying heavily on cell lines derived from female mice to
study muscle regeneration.
Discovered a novel transcription factor that modulates important steps in the transitions of adult myogenic stem cells to and from quiescence
during muscle regeneration.
Current research is looking at why inhibiting certain molecules, such as mouse protein Stat3,
promote muscle regeneration in mice and how to engineer orthopedic implants from stem cells to replace damaged cartilage and bone, but the results of that effort aren't expected to be necessarily aimed at the old.
Professor Ryoichi Nagatomi has been studying the body's adaptation to physical training, especially skeletal
muscle regeneration after an injury.
They injected an antibody to boost β1 - integrin function into aged muscles to test whether this treatment would
enhance muscle regeneration.
These side by side microscopic images reveal the dramatic effect that a novel mechanotherapy has
on muscle regeneration over a period of two weeks: no treatment is pictured (left) in contrast to direct mechanical stimulation of the muscle (right).
The team showed that REV - ERB is a regulator of muscle differentiation, and that a drug that inhibits this receptor, called SR8278,
stimulates muscle regeneration after acute injury.
Researchers at the University of Minnesota have developed an animal research model for facioscapulohumeral muscular dystrophy (FSHD) to be used for
muscle regeneration research as well as studies of the effectiveness of potential therapies for FSHD.
In their research, authors Sajedah M. Hindi, Ph.D., and Ashok Kumar, Ph.D., discovered that removing TRAF6 depletes Pax7, resulting in
reduced muscle regeneration in both normal and Duchenne muscular dystrophy (DMD) mouse models.
«We also saw that other hallmarks of
impaired muscle regeneration — fat deposits and fibrosis [scar tissue] accumulation — were also lower in the THI - treated mice.»
Strikingly, we observed that induction of either ß - catenin LOF or GOF mutations in MuSCs leads to the impairment of skeletal
muscle regeneration following injury.
During my research on appendage and
cardiac muscle regeneration, I have discovered that microRNAs (miRNAs) play a central role in this process.
«There's tremendous opportunity here,» said Jerilyn Bowers, spokeswoman for MDI Biological Laboratory in Bar Harbor, which is so excited about its heart
muscle regeneration drug that it's spun off a new company to shepherd the drug through clinical trials and to work on other regeneration possibilities.
Topics such as the mechanisms of cell injury in normal and dystrophic muscle,
compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.
It aids in
quicker muscle regeneration efficiently and prepares you for the workout, next day, irrespective of the intensity of the workout.
Abstract
During muscle regeneration, the conversion of muscle stem cells to terminally differentiated myofibers requires multiple cell fate transitions.
That being said, the production of pro-inflammatory cytokines is associated with insulin resistance, obesity and metabolic syndrome, whereas a higher production of anti-inflammatory cytokines has been shown to improve insulin sensitivity (which helps protect the organism from developing diabetes and cardiovascular diseases), decrease fat storage,
enhance muscle regeneration and support longevity.
Studies of satellite cell activation via nitric oxide have opened an exciting area of research
on muscle regeneration, growth and the muscle - fiber cytoskeleton that integrates mechanical and biochemical signal transduction with cell and molecular biology of muscle tissue in growth, development, disease, aging and evolution.
The lead candidate, MSI - 1436, stimulates
heart muscle regeneration, improves heart function and increases survival following heart attack in animal models.
The aim or our team is to understand the role of the interactions myogenic cells develop with their environment in the regulation of
skeletal muscle regeneration and their impact in the pathological context of degenerating myopathies.
Advancement of Research for Myopathies Research Grants The program's purpose is to accelerate biomedical research aimed at developing treatments for Autosomal Recessive Vacuolar or Inclusion Body Myopathies associated with GNE mutations and skeletal
muscle regeneration.
Investigations aimed at determining the downstream targets of LIF would help to clarify the functional importance of LIF in
muscle regeneration, and further its potential application in cell transplantation therapy.»
Hindi, a post-doctoral fellow, and Kumar, professor and distinguished university scholar in UofL's Department of Anatomical Sciences and Neurobiology, believe this is because TRAF6 is upstream from Pax7 in the signaling process involved in muscle repair and orchestrates multiple signals controlling
the muscle regeneration process.
In the course of this work, Burris and Flaveny have explored the roles of the nuclear receptor REV - ERB, which regulates key processes in the body, from sleep to cholesterol, and, most recently,
muscle regeneration.
This suggested that a defect in skeletal
muscle regeneration may contribute to muscle loss in FSHD.
But when even low doses of doxycycline were given to the recipients to turn on DUX4 in the skeletal muscle stem cells,
muscle regeneration was severely impaired.
A trace substance in caramelized sugar, when purified and given in appropriate doses, improves
muscle regeneration in a mouse model of Duchenne muscular dystrophy.
Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal
muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries.
In addition to the functions in the brain described here, BAI1 is also thought to have functions in
muscle regeneration and in the engulfment and removal of dying cells.
One explored the potential of GDF11 in
muscle regeneration and the other in brain regeneration.
Phrases with «muscle regeneration»