In comparison with mice, delivery of treatments to
affected nervous system tissues can be better tested in pigs, because their size is closer to that of humans.
In mouse studies, RG3039 increased the expression of SMN in
central nervous system tissue by only about 50 % — a «pretty modest» amount, admits Rusche.
These cells further damage the central
nervous system tissue by causing neuronal cell death and scar formation that blocks recovery from paralysis.
Unsupervised clustering of cell - type - specific lncRNAs and trait associations showed that related cell types and traits tend to clump together in biologically plausible ways: for example, lncRNAs enriched
in nervous system tissues tended to be associated with neuropathy and behavior traits, and the odds ratios of lncRNA genes were comparable to those of mRNA genes.
Multiple sclerosis (MS) is among the most common neurological diseases in young adults, affecting 350 000 individuals in the United States and 2 million worldwide.1 Prevailing thought is that MS is an autoimmune disorder whereby an unknown agent or agents triggers a T cell — mediated inflammatory attack, causing demyelination of
central nervous system tissue.2
This surely contributes to the rarity or nonexistence of human - to - human transmission of rabies (acquired by the bite of an infected dog or bat); cat - scratch disease (which causes skin lesions and swollen lymph nodes); tularemia (a disease, often acquired when hunting and cutting up an infected rabbit, that can cause skin ulcers, swollen lymph nodes, and fever); and BSE (probably acquired by eating
the nervous system tissue of infected cows).
However, this type of treatment would need to be regularly delivered to
nervous system tissues.
This protein conformation apparently stupendously reduces the capacity for apoE to shuttle trace metals out of
nervous system tissues.
Distemper in domestic dogs is a highly contagious, often fatal viral disease that affects respiratory, urogenital, gastrointestinal, ocular and central
nervous system tissue.