The phrase
"small molecules" refers to chemicals or substances that are made up of just a few atoms. These substances are usually very small in size and have a simple structure.
Full definition
An ideal model for the evaluation
of small molecule inhibitors in two disease models simultaneously.
By differentiating cells over and over under various conditions, his group intends to use them to screen
for small molecules that might interfere with the disease process.
Those features present significant challenges in drug discovery, and in fact, DNA - binding proteins traditionally have been considered to be beyond the reach of even
small molecule inhibitors.
She also investigated the mode of action for such
small molecules in controlling bacterial behaviors.
Researchers focused on two species of bacteria that break up dietary fibers from food into
small molecules called short - chain fatty acids.
The scientists report that the next step is to identify this cell - to cell signal and attempt to block it
using small molecules.
Food and drink must be changed
into smaller molecules of nutrients before the blood absorbs them and carries them to cells throughout the body.
This is believed to be the first study to focus
on small molecules associated with this disease.
The smart gel could provide structural rigidity in organs such as the lungs, and can contain
small molecules like water or drugs to be transported in the body and released.
The platform serves as a potential way to help researchers quickly discover new carriers for a broad range of treatments,
from small molecules to gene therapies.
However, it's not easy to
design small molecules against transcription factors — by their nature they don't have a molecular structure we can easily design blocking chemicals against.
First, the fungi accumulate sugars and
other small molecules in their cells, which, in turn, brings in more water.
Protein is a compound comprised of chains of
smaller molecules known as amino acids, and it's the basic building block of your body.
«When we discover a
new small molecule, we have the advantage of knowing that it works in vivo,» he says.
We're convinced, based on this result, that we can put together a platform that would enable on - demand assembly of
complex small molecules.
Plants are capable of making tens of thousands of
different small molecules — an average leaf for example, produces around 20,000.
This barrier works to protect the brain from toxins by allowing
only small molecules to pass through.
The GI tract is where we break down food into
much smaller molecules, that are then absorbed and used by the body to make energy, repair tissue, and clear toxins.
The acidity of urine — as well as the presence of
small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows.
These large molecule drugs differ from traditional pharmaceuticals in that they are usually injected, while
small molecule pharmaceuticals are taken in tablet form.
However,
while small molecule drugs can cause unwanted side effects because they are easily absorbed in the body, protein drugs can have the opposite problem: they can be too big.
The team discovered that
adding small molecules made from amino acids in the outer coordination sphere increased the speed without requiring additional energy to drive the catalyst.
These methods are useful in studying protein - protein interactions and identify and
optimize small molecule drugs to inhibit these interactions.
PROFESSIONAL SUMMARY * An experienced scientist with excellent managerial and training skills in
small molecule analysis.
But the mechanisms involved in most diseases are inside cells, and reaching those
requires small molecules, at least for now.
Works with start - up company to navigate a complex
small molecule patent landscape and develop an exclusivity proposition attractive to large pharmaceutical partners.
Their analysis identified a series of
possible small molecules that make economic sense and could be made by converting captured CO2.
We are working on how to screen for and
isolate small molecules to impact that pathway and test them in animal models for a number of different diseases.
The bacteria break up large molecules that the host can not digest, and the host in turn absorbs many of the
resulting small molecules for energy and nutrients.
The human body builds all the different kind of proteins it needs for these tasks by
putting smaller molecules called «amino acids» into chains.
The automated process has the potential to greatly speed up and enable new drug development and other technologies that rely
on small molecules.
Small molecule drugs were used to inhibit the function of a cellular pathway associated with protein synthesis.
Second is the lack of understanding of the detailed molecular mechanisms of regeneration and thus the lack of identified proteins that can be targeted
with small molecules.
However, a different solution is required
for small molecules because they lack a common functional group that can be employed for attachment to the solid phase.
The newly crafted molecule is non-toxic, simple to produce, and cost - effective compared to the production of alternate treatment strategies, such as antibodies and
small molecule inhibitors.
To use fructose for energy, the body needs to convert it into another type of simple sugar called glucose or into
other smaller molecules.
During digestion, they make vitamins that are vital for life, send signals to the immune system, and
make small molecules that can help your brain work.
Phrases with «small molecules»