Estrangement refers to a state or condition in which two or more people, who were once close and had a strong emotional bond, have become distant from each other. It can be due to various reasons such as disagreements, misunderstandings, lack of communication, growing apart, etc., leading to an absence of affection, intimacy, and connection between them. Estrangement can also refer to the act of withdrawing or separating oneself from something or someone, resulting in a sense of detachment or disconnection.