The phrase "greatest failure" refers to the biggest and most significant mistake or disappointment experienced by someone in their life or career.
Sentences with «greatest failure»
However the single greatest failure of this game is its complete lack of online connectivity, in many ways it's a step backwards and this will greatly affect the titles longevity. (teamvvv.com)
The other great failure is that of the museums and of public support generally. (juddfoundation.org)
Governments always have to take the blame for great failures of public policy. (dailymail.co.uk)