Definition of «homologous recombination»

Homologous recombination is a process in which two DNA molecules, or homologous sequences, exchange genetic information to repair errors that occur during replication. This type of recombination occurs naturally and can also be induced experimentally by exposing cells to certain chemicals or radiation. Homologous recombination plays an important role in maintaining the integrity of DNA and preventing mutations that could lead to diseases such as cancer.

Sentences with «homologous recombination»

  • Indeed, at least in part, the abnormalities in homologous recombination deficiency have contributed to the very outstanding responses to platinum therapy and very striking new data with PARP (poly [ADP - ribose] polymerase) inhibitors. (cancernetwork.com)
  • Cancer Network: What are the ways to test for this deficiency of homologous recombination in patients with ovarian cancer? (cancernetwork.com)
  • Caris performed the molecular profiling on 48,733 solid tumor samples to assess the prevalence of homologous recombination deficiency in about 20 different types of solid tumors. (sciencedaily.com)
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