The term "loaded" has multiple meanings depending on its context.
1) In a general sense, it can refer to something that is fully or heavily laden with something else; for example, "the truck was loaded with cargo."
2) It can also be used in the phrase "to be loaded," which means being intoxicated from drugs or alcohol. For instance, "he was so drunk last night and didn't even remember what happened - he must have been loaded!"
3) In a figurative sense, it can mean having an abundance of something; for example, "she is just too lucky to be believed – she has everything going her way, she’s definitely loaded."