Lyme is a small town in Connecticut, United States. However, when referring to Lyme disease, it refers to an infectious disease caused by bacteria from the Borrelia genus. It is commonly spread through the bites of infected blacklegged ticks and can cause symptoms such as fever, headache, fatigue, and a characteristic rash. If left untreated, Lyme disease can lead to more serious complications involving joints, heart, and nervous system.