Sclerosis refers to a condition in which tissues or organs become hardened and lose their normal function. It can affect various parts of the body, including the liver (cirrhosis), lungs (pulmonary fibrosis), kidneys (glomerulosclerosis) and brain (multiple sclerosis). The cause of scelerosis varies depending on which organ is affected. It can be caused by chronic inflammation, autoimmune diseases or infections. Treatment for sclerotic conditions depends on the underlying cause and may include medications to reduce inflammation, control symptoms or slow disease progression.