The phrase "significant hit" means a big impact or a substantial effect on something or someone.
Sentences with «significant hit»
Perhaps the most significant hit on your bank account won't come from the fine or the penalty from law enforcement. (4autoinsurancequote.com)
I think it was the perfect storm of things — the show took a really significant hit. (thedrinksreport.com)
This approach allows you to identify a comprehensive list of statistically significant hits prior to a more detailed biological analysis. (mdanderson.org)