In support of this notion, KLF4 has been found to be frequently overexpressed in 70 % of breast cancers, and its localization in the nucleus of breast cancer cells has been identified as a marker of aggressive phenotype in early - stage infiltrating ductal carcinoma (30). (cancerres.aacrjournals.org)
Nuclear localization of KLF4 is associated with an aggressive phenotype in early - stage breast cancer (cancerres.aacrjournals.org)
Mutations in fms related tyrosine kinase 3 (FLT3) gene are the most common mutations found in acute myeloid leukemia (AML) and are characterized by an aggressive phenotype with a high prevalence of relapse. (invivoscribe.com)