We also show that inhibition of the PI3K / AKT pathway in ALK + ALCL cell lines decreased the level of phosphorylation of mTOR and mTOR signaling proteins. (cancerres.aacrjournals.org)
We found that mTOR signaling is frequently activated in ALK + ALCL (Fig. 1). (cancerres.aacrjournals.org)
These responses were seen for patients with a variety of types of cancer: NSCLC; colorectal cancer; mammary analog secretory carcinoma of the salivary gland with NTRK1 / 2/3 gene fusions; NSCLC with ROS1 gene fusions; and NSCLC and colorectal cancer with ALK gene fusions. (sciencedaily.com)