An important impact of the Hematopoietic Stem - Cell Gene Therapy described in the paper, is that it allows for the use of autologous CD34 + cells, thereby avoiding complications associated with allogeneic transplantation. (clinicalresearchforum.org)
Most multiple myeloma patients, however, are ineligible for allogeneic transplantation due to age and medical restrictions. (cancerresearch.org)
Hutter G and Thiel E Allogeneic transplantation of CCR5 - deficient progenitor cells in a patient with HIV infection: an update after 3 years and the search for patient no. 2. (stemcellsportal.com)