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Phrases with «allosteric modulators»

Allosteric modulators are substances that can control how proteins work. They can attach to a protein in a place that is different than where other substances usually attach, and change the protein's shape or activity. This can either increase or decrease the protein's function, making allosteric modulators useful for regulating key processes in the body. Full definition

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Sentences with «allosteric modulators»

  • Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference. (inb.u-bordeaux2.fr)
  • With Jan Stichel at Annette Beck - Sickinger's lab, Leipzig University, Germany and David Weaver, head of the high - throughput screening facilities at Vanderbilt University, I will be screening Vanderbilt's library of small molecules for potential allosteric modulators of the human Y4 receptor. (meilerlab.org)
  • The PI of the proposal has also experience in cheminformatics method development for chemical biology and therapeutic development (Mueller, R., et al.; «Discovery of 2 -(2 - Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound»; ChemMedChem; 2012; 7; 406). (vicc.org)
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