"Brain metastases" refers to cancer cells that have spread from another part of the body to the brain. It means that the cancer has spread into the brain and formed new tumors there. Full definition
[32] In patients with brain metastases in the AZD3759 phase I clinical trial, 63 % (12 of 19 patients) achieved an intracranial response and 50 % (10 of 20 patients) had an extracranial response. (cancernetwork.com)
Many lung cancer trials have traditionally excluded patients with brain metastases at baseline, expecting that the presence of metastases would create negative results that could in turn create the appearance of drug failure. (sciencedaily.com)
Stereotactic radiosurgery is an effective and commonly used treatment for brain metastases, but intracranial tumor progression is frequent after SRS alone, primarily because of the development of new metastatic lesions. (sciencedaily.com)