Ralf Kittler (Buchholz, MPG)-- «Functional genomic analysis of cell cycle progression in human tissue culture cells» (2006) (dresden-ipp.de)
«It completely turns upside - down what was thought to be a fundamental aspect of cell cycle progression in all cancer cells driven by one of the most common genetic pathways mutated in cancer, namely the p16 - cyclin D pathway.» (sciencedaily.com)
Once freed, the proteasome degrades proteins required for cell cycle progression, thus driving cells into senescence. (medicalxpress.com)