Under basal growth conditions, 1235 genes were essential for cell fitness at a false - discovery rate of 5... (fgr.hms.harvard.edu)
Chromosomal instability (CIN) often results in aneuploidy, which compromises cell fitness and leads to cell death. (irbbarcelona.org)
For the Sc2.0 project it is now clear that despite densely spaced clusters of edits (mean distance of ~ 400bp), the overall design is robust as few «bugs», or designer changes that affect cell fitness, have been uncovered. (engineeringbiologycenter.org)