The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility. (sciencedaily.com)
The Exocyst complex, which functions in polarized exocytosis, has been involved in regulation of cell motility. (science.institut-curie.org)
Taken together, these results strongly suggest that the LPA2 signaling modulates T cell motility in the confined environments at least partly in an integrin - independent manner and may also act on cell adhesion to prevent over-adhesion to the substrates. (elifesciences.org)