BM biopsy demonstrated a markedly hypercellular marrow with multiple interstitial aggregates of spindled mononuclear cells with dark smudged chromatin moderate to abundant gray cytoplasm, which comprise approximately 60 - 70 % of the total cellularity of the specimen. (thejh.org)
The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS). (sciencedaily.com)
Currently the diagnosis is made via an invasive bone marrow biopsy and histophatology to assess cellularity and reticulin deposition in the marrow. (sciencedaily.com)