As an intermediate and advanced trainee, not only do you have to worry about longer periods of peripheral fatigue, but you also have to worry about central fatigue. (chestsculpting.com)
As you get better at doing an exercise, you get better at putting stress on your body — both on your central nervous system (causing central fatigue) and on your peripheral systems (peripheral nerves, muscles, and vascular system). (chestsculpting.com)
Caffeine may also modulate central fatigue, a type of fatigue caused by neurochemical changes in the brain associated with prolonged exercise, and in turn influence ratings of perceived exertion, perceived pain, and levels of vigour, all of which are likely to lead to improvements in performance11, 12. (coffeeandhealth.org)