Based on the nucleotide context, the authors suggest that a new mutational mechanism may be at work involving cytosine deamination of single - stranded DNA (presumably during replication). (massgenomics.org)
The SureSeq mix increases the success and accuracy of hybridization - based NGS for FFPE samples by repairing damage such as nicks and gaps, oxidized bases, blocked 3» ends, and deamination of cytosine to uracil. (sciencemag.org)
Gluconeogenesis from protein requires deamination, and the nitrogen molecule is then used to manufacture ammonia and urea that are both poisonous. (drrosedale.com)