Nevertheless, progesterone elevation does cause glucose intolerance and overt diabetes during diestrus in bitches (126,127). (academic.oup.com)
If she remains unfertilized, she will stay in diestrus for 60 — 90 days. (breeders.net)
The periodic influence of diestrus - associated insulin resistance may contribute to the increased risk of female compared with male dogs for developing diabetes and highlights the role that environmental influences may play in the pathogenesis of canine diabetes. (academic.oup.com)