The phrase "different ballgame" means that things have changed a lot or that the situation is now completely different from what it was before. Full definition
It's a whole different ballgame in online play, however, which adds a refreshing extra level of strategic depth. (heypoorplayer.com)
When it comes to services, it's an entirely different ballgame altogether. (ungerandkowitt.com)
Creating resumes that get results is a completely different ballgame in this computer age, and today we'll share some of the major reasons why. (awai.com)