A genetic cure for the disease would require completely replacing the mutated gene because any remaining dysfunctional protein would continue to form damaging aggregates. (scientificamerican.com)
Unfoldases are able to recognize, unfold, and address misfolded or dysfunctional proteins towards proteolytic complexes. (epn-campus.eu)
If a piece of mRNA is found to be defective, it is destroyed so that it can not go on to produce dysfunctional proteins that can harm the cell. (gladstone.org)