Dysfunction in telomere maintenance pathways plays an integral role in aging, cancer, and certain rare diseases such as dyskeratosis congenita (DC). (sciencemag.org)
For now, the only diseases clearly caused by shortened telomeres or dysfunctional telomerase are rare premature aging disorders like dyskeratosis congenita. (discovermagazine.com)
This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand. (sciencedaily.com)