In the paper, JAX Professor Martin Pera, Ph.D., and Assistant Professor Christopher Baker, Ph.D., note that more refined knowledge of the differences between pluripotent and totipotent stem cells is needed, particularly the molecular regulatory networks that govern cell fate decisions in early mammalian development. (jax.org)
To be able to apply systems biology tools to early embryonic mitosis, we will push light - sheet - based imaging technology development further to improve its light efficiency and resolution in order to establish a physiological molecular model for early mammalian development and infertility. (embl.de)
These findings on gene expression in single embryonic stem cells are in concert with recent studies of early mammalian development, which reveal molecular heterogeneity and a stochasticity of gene expression in blastomeres. (journals.plos.org)