«What these new findings on exhausted T cells tells us is that the unique epigenetic profile of exhausted T cells causes these cells to express a different overall set of genes compared to memory or effector T cells,» Wherry said. (sciencedaily.com)
«Combined with the advancement of DNA sequencing technologies to capture epigenetic profiles in unique clinical samples, researchers can make discoveries that were previously not possible,» said Dr. Corley. (sciencedaily.com)
They identified progressive loss of DNA methylation in certain parts of the genome, and reported that memory T cells in the blood had distinct epigenetic profiles from those in the bone marrow. (the-scientist.com)