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Phrases with «epigenetic silencing»

"Epigenetic silencing" refers to the process in which certain genes in our DNA are effectively switched off or deactivated. It occurs when certain chemical modifications are added to our DNA or the proteins that package our DNA, resulting in these genes not being expressed or used to create proteins. This can have significant effects on how our cells function and can contribute to the development of various diseases or other biological changes in our body. Full definition

Sentences with «epigenetic silencing»

  • These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets. (massgenomics.org)
  • Six speakers were ultimately selected to represent the next generation of cancer researchers, including GMI's very own Angela Ting for her work on RNA - mediated epigenetic silencing in human cancers. (lerner.ccf.org)
  • SQLE increased the NADP + / NADPH (reduced form of NADP +) ratio, which triggered a cascade of events involving oxidative stress — induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A - mediated epigenetic silencing of PTEN, and activation of AKT - mTOR (mammalian target of rapamycin). (stm.sciencemag.org)
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