They developed a derivative of amphotericin that, at least in cell culture, binds to ergosterol in yeast but not to human cholesterol. (sciencedaily.com)
Via in vitro experiments, the researchers proved that most larvae completed pupal morphogenesis when the larval food was inoculated with the fungus and when only ergosterol was added. (sciencedaily.com)
By inactivating a yeast gene, the researchers stopped the production of a yeast steroid called ergosterol and instead allowed its precursors to accumulate. (sciencemag.org)