These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance. (sciencedaily.com)
Therefore, the mechanism proposed behind decreased female central insulin sensitivity is a modulation caused by brain estrogen signaling, potentially mediated by estrogen effects on ERα in various regions of the hypothalamus. (academic.oup.com)
It is possible that Notch regulation by estrogen is context dependent, but our data clearly show that hypoxia activates estrogen signaling, resulting in increased Notch1 cleavage and activation of downstream targets. (cancerres.aacrjournals.org)