Some medicines and grapefruit juice may increase the level of ethinyl estradiol in your blood if used together, including: (nuvaring.com)
And in several rivers around the world, endocrine disruptors such as ethinyl estradiol (EE2), the main component in most oral birth control pills, have been linked to the feminization of male fish. (sciencemag.org)
That means ethinyl estradiol is freely available but the natural hormones, which do bind to SHBG, are very unavailable. (virginiahopkinstestkits.com)