The results pinpoint a critical intermediate step in the chemical pathway that leads to amyloid fibril formation. (sciencedaily.com)
«Taking a drug to promote fibril formation could be one way to reduce toxicity in SOD1 - ALS,» Dokholyan said. (sciencedaily.com)
Products from an early stage of fibril formation were even more toxic to cells than the final, fibrillar form — just as some researchers suspect is the case for early stages of protein misfolding in Alzheimer's disease. (sciencemag.org)