An analysis of all gene transcription in the cultured cell lines turned up a large gene complex in which gene expression differed conspicuously in cells from patients compared to controls. (sciencedaily.com)
A major consequence of such interspecific hybridization may be outbreeding depression due to the break - up of co-adapted gene complexes and disruption of local adaptations (Barton & Hewitt 1989). (rsbl.royalsocietypublishing.org)
«We found dysregulated expression in a suspect gene complex which adds to evidence that PMDD is a disorder of cellular response to estrogen and progesterone,» explained Peter Schmidt, M.D. of the NIH's National Institute of Mental Health, Behavioral Endocrinology Branch. (sciencedaily.com)