While MDA has become the preferred amplification method for projects seeking single - nucleotide variations, labs looking for gene copy number variations often prefer a method called «multiple annealing and looping - based amplification cycles» (MALBAC). (sciencemag.org)
About 90 % of solid tumors display whole - chromosome aneuploidy, while many tumors with diploid karyotypes nonetheless harbor segmental or arm - length aneuploidies that also result in significant gene copy number alterations. (cshl.edu)
The TGen team performed deep genomic profiling, integrating gene copy number, gene expression and DNA methylation datasets on a collection of 35 breast - brain metastases samples. (sciencedaily.com)