Although gene therapy vectors delivered to brain were used for this research, Davidson envisions developing a small molecule that can appropriately modulate this pathway. (sciencedaily.com)
Now the Boston Children's research team reports restoring a much higher level of hearing — down to 25 decibels, the equivalent of a whisper — using an improved gene therapy vector developed at Massachusetts Eye and Ear. (sciencedaily.com)
The results drew attention in part because they come from the lab of James Wilson at the University of Pennsylvania, who led a 1999 trial in which a teenager died from an immune reaction to a different gene therapy vector. (science.sciencemag.org)