«Through further functional studies we found that myosin IIa is also required for activation of the main guardian of the genome — a tumor suppressor protein called p53.» (sciencedaily.com)
Indeed, a plethora of research reports has implicated the master guardian of the genome, p53, as being a major hindrance to the iPS induction process [33]--[38]. (journals.plos.org)
The finding shows that p53, sometimes described as the «guardian of the genome», has been around for over 1 billion years. (newscientist.com)