Each guide RNA might hit a single gene or multiple genes, depending on the particular guide sequence. (sciencedaily.com)
This additional RNA must contain a sequence complementary to the substrate [external guide sequence (EGS)-RSB- and a 3» - proximal CCA sequence to ensure cleavage. (science.sciencemag.org)
Her team's full Argonaute structure, published in 2005, definitively solved a key part of the mystery: the protein features a groove into which tiny guide sequences of RNA can nestle. (cshl.edu)