The phrase "huge setback" means a significant or major obstacle or problem that causes a delay or setback in achieving a goal or making progress. Full definition
In order to keep my eye on the prize, even when huge setbacks occur, I always come back to the inspiration of my vision as the key to unlocking my motivation. (entrepreneur.com)
Out, alas, until November; a shocking blow to his club and huge setback for England. (worldsoccer.com)
I think it is very important to be well - rounded in this business, because when conditions change you have to be able to adapt, and starting from scratch every time will cause HUGE setbacks! (biggerpockets.com)