The last part of our program is based on the fact that iPS cell lines which express a disease - related mutant gene could represent a relevant human cellular model for disease modeling and drug screening. (istem.eu)
The project will analyse the chemical changes that occur in Unkempt in human cellular models of TSC. (kcl.ac.uk)
Monogenic diseases are often lacking of physiological human cellular models dedicated to the study of the molecular mechanism implicated in the development of the pathology. (istem.eu)