To test their hypothesis, the researchers carried out experiments on human melanoma cells, a line of cancer cells they chose for their ability to grow easily and quickly. (sciencedaily.com)
As a result, the researchers were able to prevent the growth and malignant spread of the cancer in the animal model and human melanoma cells. (sciencedaily.com)
After exploiting a technology that allowed them to activate each of nearly 16,000 genes individually in human melanoma cell lines containing mutant BRAF, the authors then treated the panel of cells with the drugs and monitored which cells showed altered drug sensitivity. (science.sciencemag.org)