iPSCs created through the reprogramming of human somatic cells retain genomic marks of the donor's age. (the-scientist.com)
In late 2007, the development of IPS cells from human somatic cells prompted great excitement in the field providing the potential for researchers to obtain pluripotent stem cells without the controversial use of embryos and also to produce them on a much larger scale than would be feasible using embryos. (sciencemag.org)
The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. (sens.org)