Notably, she discovered the relationship between AD and the abnormal hyperphosphorylation of tau, which opened a new area of research in neurodegeneration, especially related to AD and tauopathies. (gladstone.org)
Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid - β (Aβ) as an important contributor to Alzheimer's disease (AD) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. (actaneurocomms.biomedcentral.com)
We were unable to demonstrate the presence of amyloid plaques, dystrophic neurites, neuronal loss, macro - or micro-gliosis, aberrant cell cycle re-entry, oxidative stress, tau hyperphosphorylation, or upregulations of proinflammatory cytokines or stress signaling molecules in the retina. (content.iospress.com)