The study was performed using several founder lines, bred onto a background strain of mice hypomorphic for BubR1 (BubR1H / H), a key component of the mitotic checkpoint machinery. (sens.org)
We describe a heteroallelic, hypomorphic genotype of mutantInR, which yields dwarf females with up to an 85 % extension of adult longevity and dwarf males with reduced late age - specific mortality. (science.sciencemag.org)
The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal († XPCS). (journals.plos.org)