Objective: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. (molecularmetabolism.com)
The mice without an adipocyte clock and shifted feeding rhythms developed obesity, as well as changes in the relative amounts of various TGs stored in adipocytes, circulating in the plasma, and present in hypothalamic neurons associated with energy balance (31). (academic.oup.com)
To explain the less commonly researched «discomfort when hungry» phenomenon, researchers at the Howard Hughes Medical Institute (HHMI) Janelia Research Campus hypothesized that specific hypothalamic neurons stimulate food - seeking behaviors to eliminate the negative feelings associated with energy deficit. (sciencedaily.com)