«The IMM teams showed clearly that the gene was switched on only in hypoxic regions,» says Sue Kingsman, the research director of Oxford BioMedica. (newscientist.com)
One percent oxygen was used to represent hypoxia, although levels of oxygen will also vary within hypoxic regions of tumors. (cancerres.aacrjournals.org)
Consequently, they discovered that by blocking Nrp1, macrophages were no longer able to migrate inside hypoxic regions in the tumor. (sciencedaily.com)