Background: Expression of programmed death ligand (PD - L1 / B7 - H1 / CD274) represents a mechanism of immune escape for renal cell carcinoma (RCC) cells. (jcancer.org)
Chris Plowe at the University of Maryland in Baltimore, who works on AMA - 1 vaccines, says agencies that fund vaccine trials do not test for effects on pathogens beyond monitoring for immune escape. (newscientist.com)
«This is the first study to illustrate that a structural abnormality in the 3» untranslated region of the PD - L1 gene causes an abnormally high production of PD - L1 protein, consequently aiding cancer immune escape,» says one of the lead authors, Keisuke Kataoka, at Kyoto University. (sciencedaily.com)